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. 2015 Jun 9;10:1075–1083. doi: 10.2147/COPD.S80091

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© 2015 Bafadhel et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Scatter correlation plot of sputum neutrophils (x-axis) with pathogen-specific bacterial load (y-axis) for samples above the limit of detection (qPCR LLD >1×10⁴ copies/mL of sputum).

Notes: Data were categorized into respective sputum culture pathogens (NSG, HI, MC, SP, and SA). (A) HI. (B) MC. (C) SP. (D) SA pathogen-specific qPCR. The horizontal dashed line on the y-axis related to pathogen-specific qPCR bacterial load of 10⁶. The vertical dashed line on the x-axis related to sputum neutrophil count at 60% (neutrophilic airway inflammation).

Abbreviations: NSG, nonsignificant growth; HI, Haemophilus influenzae; LLD, lower limit of detection; MC, Moraxella catarrhalis; qPCR, quantitative real-time polymerase chain reaction; SP, Streptococcus pneumoniae; SA, Staphylococcus aureus.