Table 1.
Determination of concentration of HA coating on NLC surface
| HA concentration | Zeta potential (mV)* | Particle size (nm)* | Encapsulation efficiency of 5-FU (%)* | Encapsulation efficiency of CDDP (%)* |
|---|---|---|---|---|
| 0.05% | +37.5±3.1 | 99.5±2.1 | 92.5±2.5 | 89.9±3.1 |
| 0.1% | +33.9±2.9 | 128.3±3.7 | 91.6±2.1 | 88.6±3.7 |
| 0.2% | +26.4±2.3 | 181.2±3.1 | 90.5±2.6 | 89.5±2.9 |
| 0.3% | +25.9±2.6 | 185.7±9.3 | 78.4±3.5 | 61.6±7.1 |
| 0.4% | +26.1±2.2 | 348.9±25.6 | 69.1±3.9 | 49.1±6.1 |
Note:
*
Data is presented as mean ± standard deviation.
Abbreviations: HA, hyaluronic acid; NLC, nanostructured lipid carriers; FU, fluorouracil; CDDP, cisplatin.