Table 2.
Physicochemical characterization of different NLC complexes
| Formulation | Particle size (nm) | PDI | Zeta potential (mV) | EE of 5-FU (%) | EE of CDDP (%) |
|---|---|---|---|---|---|
| Blank NLC | 95.8±2.1 | 0.12±0.01 | +45.3±3.5 | NA | NA |
| FU-NLC | 131.4±2.3 | 0.16±0.02 | +37.3±2.3 | 91.9±1.9 | NA |
| C-NLC | 118.2±2.8 | 0.13±0.02 | +35.1±1.9 | NA | 89.5±2.8 |
| FU/C-NLC | 145.3±2.9 | 0.19±0.03 | +29.7±2.1 | 91.1±2.5 | 88.7±3.1 |
| HA-FU/C-NLC | 181.6±3.2 | 0.21±0.04 | +26.3±2.4 | 89.8±2.9 | 89.1±2.1 |
Note: Data is presented as mean ± standard deviation.
Abbreviations: NLC, nanostructured lipid carriers; PDI, polydispersity index; EE, encapsulation efficiency; FU, fluorouracil; CDDP, cisplatin; NA, not applicable; C, CDDP-loaded; HA, hyaluronic acid.