Table 4.
IC50 and CI50 values of NLC formulations with different 5-FU/CDDP ratios
| Drug solutions | 5-FU/CDDP ratio (w/w) | IC50 5-FU (μg/mL) | IC50 CDDP (μg/mL) | CI50 |
|---|---|---|---|---|
| FU-NLC | NA | 6.52 | NA | NA |
| C-NLC | NA | NA | 0.98 | NA |
| FU/C-NLC | 20:1 | 3.2 | 0.16 | 0.65 |
| FU/C-NLC | 10:1 | 4.9 | 0.49 | 1.25 |
| HA-FU/C-NLC | 20:1 | 1.5 | 0.08 | 0.31 |
| HA-FU/C-NLC | 10:1 | 3.2 | 0.32 | 0.82 |
Abbreviations: IC50, half maximal inhibitory concentration; CI50, combination index calculated when using the IC50 values of the drugs; NLC, nanostructured lipid carriers; FU, fluorouracil; CDDP, cisplatin; C, CDDP-loaded; HA, hyaluronic acid; NA, not applicable.