Table 5.
Prediction of subsequent EOPE during gestational weeks 8–13 by using MC and first-trimester maternal serum biomarker levels as risk predictors. For each risk model, the modeled detection rates are shown with different FPRs together with ROC curve AUC.
| RISK MODEL | LOGISTIC REGRESSION MODELED DETECTION RATE AND ROC AUC (95% CONFIDENCE INTERVAL) | |||
|---|---|---|---|---|
| FPR 5% | FPR 10% | FPR 15% | AUC | |
| Model 1. (MC) | 10% (4–20%) | 21% (12–33%) | 29% (18–42%) | 0.64 (0.57–0.71) |
| Model 2. (MC + PAPP-A + fhCGβ) | 19% (10–31%) | 26% (16–38%) | 35% (24–49%) | 0.66 (0.59–0.74) |
| Model 3. (MC + PAPP-A + fhCGβ + PlGF) | 27% (17–40%) | 32% (21–45%) | 35% (24–49%) | 0.67 (0.59–0.74) |
| Model 4. (MC + PAPP-A + fhCGβ + AFP + PlGF) | 23% (13–35%) | 39% (27–52%) | 45% (32–58%) | 0.69 (0.62–0.76) |
| Model 5. (MC + PAPP-A + fhCGβ + PlGF + sTNFR1) | 34% (22–47%) | 40% (28–54%) | 55% (42–68%) | 0.78 (0.72–0.84) |
| Model 6. (MC + PAPP-A + fhCGβ + AFP + PlGF + sTNFR1) | 34% (22–47%) | 48% (35–61%) | 50% (37–63%) | 0.79 (0.73–0.85) |