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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Apr 1;25(10):2100–2105. doi: 10.1016/j.bmcl.2015.03.073

Table 2.

SAR of southern amine substituent

graphic file with name nihms683673u3.jpg
Cmp R1 IC50(μM)a
1a graphic file with name nihms683673t1.jpg 0.46
1b graphic file with name nihms683673t2.jpg 0.56
1c graphic file with name nihms683673t3.jpg 2.0
1d graphic file with name nihms683673t4.jpg 0.22
1e graphic file with name nihms683673t5.jpg 2.4
1f graphic file with name nihms683673t6.jpg 6.4
1g graphic file with name nihms683673t7.jpg 9.9
1h graphic file with name nihms683673t8.jpg 4.9
1i graphic file with name nihms683673t9.jpg 9.2
1j graphic file with name nihms683673t10.jpg >25
1k graphic file with name nihms683673t11.jpg 18
1l graphic file with name nihms683673t12.jpg 9.2
1m graphic file with name nihms683673t13.jpg 1.6
1n graphic file with name nihms683673t14.jpg 2.6
1o graphic file with name nihms683673t15.jpg 0.65
1p graphic file with name nihms683673t16.jpg >25
1q graphic file with name nihms683673t17.jpg 0.89
1r graphic file with name nihms683673t18.jpg 1.3
a

Average of at least two measurements in DiI uptake assay with resynthesized or repurified compounds.