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SAR analysis of central carbon substituents
| Cmp | Structure | IC50 (μM)a |
|---|---|---|
| 1a |
|
0.055±0.014 |
| 5a |
|
19 |
| 5b |
|
>25 |
| 3k |
|
0.027±0.008 |
| 5c |
|
0.026±0.012 |
| 5d |
|
1.6 |
| 5e |
|
0.017±0.004 |
Average of at least two measurements in DiI uptake assay, ± standard error of mean when n > 2.
