Table 1.
Baseline characteristics of the two Irish sub-cohorts (the training and test sets) and the Italian validation cohort
| Irish cohort | p value | Italian cohort | ||
|---|---|---|---|---|
| Training set | Testing set | |||
| N | 117 | 87 | 122 | |
| Mean age at symptom onset (SD) | 60.8 (10.3) | 62.7 (10.4) | 0.351 | 65.6 (10.5) |
| Males | 61.5 % | 55.2 % | 0.441 | 58.2 % |
| Mean education in years (SD) | 12.0 (3.4) | 12.3 (3.0) | 0.528 | 9.1 (4.2) |
| Site of onset | ||||
| Spinal | 65.5 % | 57.0 % | 0.353 | 63.9 % |
| Bulbar | 33.6 % | 40.7 % | 36.1 % | |
| Respiratory | 0.9 % | 2.3 % | 0.0 % | |
| Median delay to diagnosis (months) | 10.0 | 12.0 | 0.444 | 8 |
| Median disease duration (months) | 17.0 | 19.0 | 0.652 | 10 |
| Mean ALSFRS-R (SD) | 35.7 (7.9) | 37.1 (7.0) | 0.194 | 39.8 (5.8) |
| FH of ALS | 12.0 % | 13.8 % | 0.861 | 8.1 % |