Table 3.
Risk for significant second primary cancers by age at diagnosis of uterine cancer (left half) and follow-up interval (right half), respectively
| SPM site (ICD-9 code) | Agea (years) | O | E | SIR (O/E) | 95 % CI | Intervalb (years) | O | E | SIR (O/E) | 95 % CI |
|---|---|---|---|---|---|---|---|---|---|---|
| Small intestine (152) | <50 | 7 | 0.27 | 26.06 | (10.44, 53.71) | ≤5 | 6 | 0.23 | 25.95 | (9.48-56.49) |
| ≥50 | 5 | 1.15 | 4.34 | (1.40, 10.14) | ≤1 | 0 | 0.03 | 0 | NA | |
| 1-5 | 6 | 0.20 | 29.47 | (10.76-64.15) | ||||||
| 5-10 | 3 | 0.38 | 7.97 | (1.60-23.30) | ||||||
| ≥10 | 3 | 0.81 | 3.69 | (0.74-10.79) | ||||||
| Colorectum (153,154) | <50 | 36 | 9.68 | 3.72 | (2.60, 5.15) | ≤5 | 58 | 9.00 | 6.45 | (4.89-8.33) |
| ≥50 | 83 | 43.36 | 1.91 | (1.52, 2.37) | ≤1 | 12 | 1.07 | 11.25 | (5.81-19.66) | |
| 1-5 | 46 | 7.93 | 5.8 | (4.25-7.74) | ||||||
| 5-10 | 29 | 14.05 | 2.06 | (1.38-2.96) | ||||||
| ≥10 | 32 | 30.00 | 1.07 | (0.73-1.51) | ||||||
| Lung (162) | <50 | 13 | 6.24 | 2.08 | (1.11, 3.56) | ≤5 | 36 | 6.22 | 5.78 | (4.05-8.00) |
| ≥50 | 59 | 30.57 | 1.93 | (1.47, 2.49) | ≤1 | 7 | 0.74 | 9.42 | (3.77-19.40) | |
| 1-5 | 29 | 5.48 | 5.29 | (3.54-7.59) | ||||||
| 5-10 | 24 | 9.73 | 2.47 | (1.58-3.67) | ||||||
| ≥10 | 12 | 20.85 | 0.58 | (0.30-1.01) | ||||||
| Breast (174) | <50 | 34 | 29.38 | 1.16 | (0.80, 1.62) | ≤5 | 52 | 13.71 | 3.79 | (2.83-4.97) |
| ≥50 | 61 | 37.13 | 1.64 | (1.26, 2.11) | ≤1 | 12 | 1.40 | 8.56 | (4.42-14.96) | |
| 1-5 | 42 | 12.31 | 3.25 | (2.32-4.43) | ||||||
| 5-10 | 21 | 20.05 | 1.05 | (0.65-1.60) | ||||||
| ≥10 | 22 | 32.75 | 0.67 | (0.42-1.02) | ||||||
| Ovary (183) | <50 | 23 | 3.68 | 6.25 | (3.96, 9.38) | ≤5 | 37 | 1.84 | 20.12 | (14.16-27.73) |
| ≥50 | 17 | 5.97 | 2.85 | (1.66, 4.56) | ≤1 | 30 | 0.20 | 152.87 | (103.12-218.25) | |
| 1-5 | 7 | 1.64 | 4.26 | (1.71-8.78) | ||||||
| 5-10 | 1 | 2.78 | 0.36 | (0.00-2.00) | ||||||
| ≥10 | 2 | 5.03 | 0.40 | (0.04-1.44) | ||||||
| Vagina (184) | <50 | 6 | 0.38 | 15.68 | (5.73, 34.14) | ≤5 | 7 | 0.29 | 24.43 | (9.79-50.34) |
| ≥50 | 10 | 1.38 | 7.22 | (3.46, 13.29) | ≤1 | 6 | 0.04 | 172.12 | (62.85-374.65) | |
| 1-5 | 1 | 0.25 | 3.97 | (0.05-22.11) | ||||||
| 5-10 | 3 | 0.46 | 6.58 | (1.32-19.23) | ||||||
| ≥10 | 6 | 1.02 | 5.86 | (2.14-12.75) | ||||||
| Bladder (188) | <50 | 5 | 1.07 | 4.69 | (1.51, 10.95) | ≤5 | 7 | 1.22 | 5.74 | (2.30-11.82) |
| ≥50 | 13 | 6.72 | 1.93 | (1.03, 3.31) | ≤1 | 3 | 0.15 | 19.69 | (3.96-57.52) | |
| 1-5 | 4 | 1.07 | 3.75 | (1.01-9.59) | ||||||
| 5-10 | 4 | 1.99 | 2.01 | (0.54-5.14) | ||||||
| ≥10 | 7 | 4.58 | 1.53 | (0.61-3.15) | ||||||
| Kidney (189) | <50 | 4 | 1.68 | 2.38 | (0.64, 6.10) | ≤5 | 7 | 1.82 | 3.86 | (1.54-7.95) |
| ≥50 | 21 | 9.47 | 2.22 | (1.37, 3.39) | ≤1 | 6 | 0.22 | 27.70 | (10.12-60.30) | |
| 1-5 | 1 | 1.60 | 330.63 | (0.01-3.48) | ||||||
| 5-10 | 9 | 2.93 | 3.07 | (1.40-5.82) | ||||||
| ≥10 | 9 | 6.40 | 1.41 | (0.64-2.67) | ||||||
| Total | <50 | 128 | 52.37 | 2.44 | (2.04, 2.91) | ≤5 | 210 | 34.33 | 6.12 | (5.32,7.00) |
| ≥50 | 269 | 135.77 | 1.98 | (1.75, 2.23) | ≤1 | 76 | 3.84 | 19.80 | (15.60-24.75) | |
| 1-5 | 134 | 30.50 | 4.39 | (3.68-5.21) | ||||||
| 5-10 | 94 | 52.37 | 1.79 | (1.45, 2.20) | ||||||
| ≥10 | 93 | 101.45 | 0.92 | (0.74, 1.12 |
Bold indicates statistical significance
SIR standardized incidence ratio, SPM second primary malignancy, O observed numbers of SPMs, E expected numbers of SPMs, CI confidence interval
aAge at diagnosis of uterine cancer
bFollow-up interval after the diagnosis of uterine cancer