Table III.
Comparison of OVA-specific IgE Ab responses induced by nCT, mCT, or dmCTs
| Treatment Groupa | Ag-Specific IgEb (reciprocal log2 titer) |
|---|---|
| nCT | 7.5 ± 0.3††c |
| E112K/KDEV | 3.3 ± 0.4** |
| E112K/KDGL | 3.3 ± 0.3** |
| E112K | 2.3 ± 0.2** |
| PBS | <2 |
a
Each mouse group was nasally immunized once a week for two consecutive weeks with 100 μg of OVA plus 0.5 μg of nCT, mCT E112K/KDEV, mCT E112K/KDGL, mCT E112K, or PBS.
b
Seven days after the last immunization, OVA-specific IgE levels in plasma were determined by ELISA.
c
The values shown are the mean ± SEM for 6–8 mice in each experimental group. **, p < 0.01, when compared with nCT. ††, p < 0.01, when compared with mCT E112K.