Table 2.

Trends in quit attempts and use of stop-smoking medications (SSMs) during the pre-varenicline period, the post-varenicline period and across the full study period.

		Pre-varenicline period (2004 to 2006–07)		Post-varenicline period (2006–07 to 2010–11)		Full study period (2004 to 2010–11)
Sample	Outcome	OR	95% CI	OR	95% CI	OR	95%, CI
Smokers	Any quit attempt since LSD	n = 2036		n = 2225		n = 3087a
		0.98	0.91–1.06	1.12	1.07–1.18	1.05	1.02–1.08
Quit attempters	2+ quit attempts since LSD	n = 979		n = 1208		n = 1706a
		1.05	0.92–1.19	1.12	1.03–1.21	1.09	1.04–1.14
Quit attempters	Dse of medication since LSD	n = 1012		n = 1220		n = 1737a
	Any SSM	1.01	0.89–1.16	1.16	1.07–1.26	1.15	1.10–1.21
	NRT gum	1.31	0.92–1.85	1.11	0.95–1.30	1.21	1.09–1.35
	NRT patch	1.23	1.04–1.47	0.87	0.76–0.99	0.96	0.90–1.03
	Other NRT	0.76	0.58–1.00	1.12	0.86–1.45	0.84	0.74–0.94
	Any NRT	1.08	0.94–1.25	0.95	0.85–1.05	0.96	0.91–1.01
	Bupropion	0.86	0.60–1.22	1.01	0.74–1.39	0.93	0.79–1.09
	Varenicline	–	–	1.40	1.26–1.56	–	–
		Introduction (0%) to pre-FDA alert (23%) 2006–07 to 2007–08		Pre-FDA alert (23%,) to pre-black box warning (23%) 2007–08 to 2008–09		Pre-black box warning (23%,) to end of study (16%,) (2008–09 to 2010–11
Sample	Outcome	OR	95% CI	OR	95%, CI	OR	95%, CI
Quit attempters	Dse of varenicline since LSD	n = 717		n = 789		n = 745
		120.79	16.81–868.13	1.04	0.79–1.36	0.69	0.51–0.93

Odds ratios (OR) indicate the average increase/decrease in likelihood of each outcome per unit increase in time (i.e. ~1 year), within each time-period; generalized estimating equation (GEE) modelling was used to account for repeated observations of the same individuals over time; ns indicate number of unique individuals within each time-period.

^aFull study ns do not equal sum of ns from the two separate time-periods because some individuals participated in both time-periods.

FDA = Food and Drug Administration; NRT = nicotine replacement therapy; CI = confidence interval; LSD = last survey date.