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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Neuroimage. 2015 Apr 24;115:7–16. doi: 10.1016/j.neuroimage.2015.04.039

Table 3.

Regional analyses of adjusted mean differences in cerebrovascular reactivity for DMN regions and hippocampus relative to occipital lobe in subjects with prehypertension/hypertension compared with normotensive subjectsa

Coefficient 95% CI
Intercept b 0.201 0.148, 0.254
PCC c −0.002 −0.036, 0.032
Inferior Parietal −0.098 −0.128, −0.067
ACC −0.214 −0.250, −0.178
Medial Frontal 0.028 −0.006, 0.061
Hippocampus −0.311 −0.356, −0.266
VRF Groupd 0.056 −0.010, 0.122
PCC × VRF Groupe −0.063 −0.106, −0.020
Inferior Parietal × VRF Group −0.024 −0.062, 0.014
ACC × VRF Group −0.055 −0.101, −0.010
Medial Frontal × VRF Group −0.050 −0.092, −0.008
Hippocampus × VRF Group −0.006 −0.062, 0.050

CVR, cerebrovascular reactivity; CI, confidence interval; DMN, default-mode network; PCC posterior cingulate/precuneus; ACC anterior cingulate.

CVR units represent log-transformed % mean change in Bold-fMRI

a

Model adjusted for age, sex, race, education, and smoking status.

b

Intercept represents mean CVR for the occipital lobe for normotensive subjects.

c

Region coefficients represent comparisons between mean CVR for each region and mean CVR for the occipital lobe (i.e., mean difference in CVR in each region relative to the occipital lobe), in normotensive subjects.

d

VRF Group coefficient represents the difference in mean CVR for the occipital lobe for those subjects with prehypertension/hypertension compared to normotensive subjects.

e

Region × VRF Group coefficients represent comparisons between mean CVR for each region and mean CVR for the occipital lobe (i.e., mean difference in CVR of each region relative to the occipital lobe), in subjects with prehypertension/hypertension compared to normotensive subjects.