Table 1.
NMDA receptor and dopamine-related gene expression changes resulting from repeated ketamine and chronic ketamine
| Gene | Model | Repeated | Chronic | References |
|---|---|---|---|---|
| grin1 | PND7 Rat-ketamine | + | nd | 42–44 |
| grin2a | PND7 rat-ketamine | + | nd | 42 |
| grin2b | PND 7 rat-ketamine | − | nd | 42 |
| grin2c | PND7 rat-ketamine | + | nd | 42 |
| TH | Adult mice-Ketamine | nd | + | 18 |
| DRD1 | Adult mice-ketamine | nd | + | 18 |
| DRD2 | Adult mice-ketamine | nd | + | 18 |
| DAT | Adult mice-ketamine | nd | + | 18 |
+: increased specific gene mRNA level; −: decreased specific gene mRNA level; nd: not determined; PND7: seven-day-old Sprague Dawley rat; Grin 1: glutamate receptor, ionotropic, NMDA1; Grin2a: glutamate receptor, ionotropic, NMDA2a; Grin2b: glutamate receptor, ionotropic, NMDA2b; Grin2c: glutamate receptor, ionotropic, NMDA2c; TH: TH tyrosine hydroxylase; DRD1: dopamine receptor 1; DRD2: dopamine receptor 2; DAT: dopamine transporter.