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. 2015 Jun 7;152(1):119–128. doi: 10.1007/s10549-015-3452-x

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Exposure to tamoxifen (AUC_0–last) in plasma and liver tissue of mice following tamoxifen administration at six different times. Tamoxifen was administered to 18 mice at six different time points. Blood was collected at six time points (3 mice/time point) after tamoxifen administration and area under the curves (AUCs_0–last) was calculated. Data are presented as AUC_0–inf (y-axis), derived from non-compartmental analysis on plasma concentration–time profiles of tamoxifen following dosing at six different times in a 24-h period (x-axis)