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Mean plasma concentration–time profiles for tamoxifen (a), endoxifen (b), N-desmethyltamoxifen (c), and 4-hydroxytamoxifen (d) following tamoxifen administration in the morning at 8 a.m. (open circles) and in the evening at 8 p.m. (closed circles) in 27 women with (a history) of breast cancer
