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. 2015 Jun 11;130(1):1–19. doi: 10.1007/s00401-015-1449-5

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — The content of intraneuronal APP is negatively correlated with spine density. a APP accumulation in GFP expressing layer V pyramidal neurons from APP23 mice (top). Dendrites that originated from the soma are shown below as high-contrast representations of maximum-intensity projected confocal images. b The dot plot is the corrected intensity of intercellular APP vs. spine density. Straight line is fitted by nonlinear regression. **p < 0.01 (F test). Figure adapted from Ref. [228]