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. 2015 Jun 16;17(1):80. doi: 10.1186/s13058-015-0586-z

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© Pang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Tumour with synchronous ductal carcinoma in situ (DCIS) and invasive carcinoma showing heterogeneity of HER2 amplification and expression. (a) HER2 immunohistochemistry (IHC) showing strong circumferential membrane staining (positive for HER2) in an area of DCIS, with negative staining in adjacent DCIS and invasive carcinoma (100×). (b) HER2 silver enhanced in situ hybridisation (SISH) of same region as (a) showing DCIS with HER2 amplification and adjacent DCIS without HER2 amplification (200×). (c) Invasive carcinoma with areas showing strong circumferential membrane staining for HER2 IHC (positive for HER2) and areas negative for HER2 (100×). (d) HER2 SISH of same region as (c) showing invasive carcinoma with areas with and without HER2 amplification (200×)