Fig. 2.

Nortriptyline treatment of neuropathic allodynia. Two weeks after Cuff implantation, the daily treatment with nortriptyline (5 mg/kg, i.p. twice a day) or its saline control (0.9 % NaCl) started and was maintained for 3 weeks. The hindpaw mechanical threshold was tested before the morning drug injection, using von Frey filaments. (A) In wild-type mice the treatments did not affect the mechanical threshold of the contralateral paw, but chronic nortriptyline suppressed the ipsilateral Cuff-induced allodynia. (B) Similar results were observed in MOR-deficient mice. Data are expressed in mean ± SEM. (n = 5–10 for the different Sham groups, n = 7–8 for the different Cuff groups).