Table 2. Association between rs931794 and lung cancer risk in a Chinese population.
Genotype | Controls (n = 1062)N(%) | Cases (n = 611)N(%) | P a | Crude OR (95%CI) | p | Adjusted OR (95%CI) b | P b |
---|---|---|---|---|---|---|---|
Successful genotype | 1058(99.6) | 562(92.0) | |||||
Overall | |||||||
AA | 503(47.5) | 235(41.8) | 1.000 | 1.000 | |||
AG | 452(42.7) | 239(42.5) | 1.132(0.908, 1.411) | 0.271 | 1.121(0.897, 1.401) | 0.315 | |
GG | 103(9.7) | 88(15.7) | 0.001 | 1.829(1.323, 2.528) | <0.001 | 1.813(1.306, 2.517) | <0.001 |
Dominant model | 1.261(1.026, 1.550) | 0.028 | 1.250(1.014, 1.540) | 0.037 | |||
Recessive model | 1.721(1.269, 2.335) | <0.001 | 1.174(1.259, 2.335) | 0.001 | |||
Allele A | 1458(68.9) | 709(63.1) | 1.000 | 1.000 | |||
Allele G | 658(31.1) | 415(36.9) | 0.001 | 1.297(1.114, 1.510) | 0.001 | 1.287(1.103, 1.501) | 0.001 |
Additive model | 1.286(1.107, 1.494) | 0.001 | |||||
NSCLC | |||||||
AA | 503(47.5) | 165(42.2) | 1.000 | 1.000 | |||
AG | 452(42.7) | 166(42.5) | 1.120(0.872, 1.438) | 0.376 | 1.102(0.856, 1.420) | 0.450 | |
GG | 103(9.7) | 60(15.3) | 0.008 | 1.776(1.234, 2.555) | 0.002 | 1.736(1.201, 2.508) | 0.003 |
Dominant model | 1.241(0.982, 1.569) | 0.070 | 1.221(0.963, 1.547) | 0.099 | |||
Recessive model | 1.681(1.194, 2.366) | 0.003 | 1.655(1.170, 2.340) | 0.004 | |||
Allele A | 1458(68.9) | 496(63.4) | 1.000 | 1.000 | |||
Allele G | 658(31.1) | 286(36.6) | 0.005 | 1.278(1.076, 1.518) | 0.005 | 1.258(1.056, 1.497) | 0.010 |
Additive model | 1.269(1.071, 1.505) | 0.006 |
Abbreviations: OR, Odds ratio; 95%CI, 95% confidence interval.
a P values were calculated by the Pearson Chi-Square test.
b Data were calculated by logistic regression model after adjusting for age, sex, and smoking status.