Table 1. Estimated associations of each genetically predicted risk factor with Alzheimer disease.
| Trait | Scaling of OR | Number of SNPs | Overall Results | Sensitivity Analyses* | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | p-Value | OR (95% CI) | p-Value | |||
| BMI | 1 SD (4.81 kg/m2) | 32 | 0.99 (0.80−1.19) | 0.779 | 1.00 (0.82−1.22) | 0.97 |
| T2D | 1 unit higher log-odds | 49 | 1.02 (0.97−1.07) | 0.535 | ||
| Fasting glucose | 1 SD (0.65 mmol/l) | 36 | 1.12 (0.97−1.30) | 0.112 | 1.19 (1.03−1.37) | 0.02 |
| Insulin resistance | 1 SD log-FI (0.60 log-pmol/l) | 10 | 1.32 (0.88−1.98) | 0.177 | ||
| SBP | 1 SD (15.4 mm Hg) | 24 | 0.75 (0.62−0.91) | 3.4 × 10−3 | ||
| Total cholesterol | 1 SD (1.03 mmol/l) | 73 | 1.94 (1.79−2.10) | 3.1 × 10−56 | 1.04 (0.95−1.13) | 0.84 |
| HDL-cholesterol | 1 SD (0.41 mmol/l) | 71 | 0.75 (0.69−0.82) | 1.0 × 10−11 | 1.01 (0.93−1.09) | 0.87 |
| LDL-cholesterol | 1 SD (0.91 mmol/l) | 57 | 2.31 (2.12−2.50) | 3.0 × 10−87 | 1.07 (0.98−1.17) | 0.14 |
| Triglycerides | 1 SD (0.83 mmol/l) | 39 | 0.96 (0.87−1.07) | 0.482 | ||
| Smoking initiation | 1 unit higher log-odds | 1 | 0.70 (0.37−1.33) | 0.278 | ||
| Smoking quantity | 10 cigarettes/day | 3 | 0.67 (0.51−0.89) | 6.5 × 10−3 | ||
| Completing university | 1 unit higher log-odds | 2 | 0.95 (0.67−1.34) | 0.752 | ||
| Length of education | 1 year of education | 1 | 0.71 (0.48−1.06) | 0.097 | ||
*Sensitivity analyses exclude SNPs where p < 0.00017 (0.05/302 unique SNPs) for AD.
log-FI, log-fasting insulin.