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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2015 Mar 16;22(4):298–303. doi: 10.1038/nsmb.2985

Figure 1.

Figure 1

Structure of Pol ν. (a) The primary structure. The N-termini of four Pol ν variants are indicated by arrowheads. Structural domains and three insertions are marked with boundary residues. (b) Ndna2 structure (left) and its superposition with bacillus Pol I 33 (grey, right). DNA is colored yellow (primer) and orange (template). The catalytic residues and incoming nucleotide in Pol I are shown as ball–and–sticks. (c) A zoom-in view of the superimposed Exo domain. Pol ν Exo site is mutated (equivalent residues in bacillus Pol I are shown in sticks) and blocked by a long loop. (d) The Thumb domain. (e) The Palm domain. Ins1–3 are marked by arrowheads (d,e).