Skip to main content
. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Genet Epidemiol. 2015 Feb 6;39(5):385–394. doi: 10.1002/gepi.21888

Figure 1. Flow chart of analytical methods for trio design.

Figure 1

a. The threshold was set as genotypic TDT p-values < 10−5.

b. The threshold was set as case-only test p-values < 10−4, excluding pairs in non-negligible LD (r2 < 0.01). The lists of selected SNPs were shown in supplementary table 5 and 6.

c. The threshold was set as the cut-point (“elbow”) along the curve for importance scores from all SNPs. The procedure proposed by Goldstein et al. [2010] is a heuristic approach to identify the top SNPs that have much higher importance scores than the rest. The lists of selected SNPs were shown in supplementary table 3 and 4.

d. The threshold of pairwise LD is set as r2< 0.1 to select the tagging SNPs.