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Transplantation of iPS-exo significantly reduced cardiomyocyte apoptosis in ischemic myocardium. (A–C) Heart sections from PBS, CF-exo, or iPS-exo treated mice were co-stained with TUNEL and cTnI antibody. Representative images of TUNEL staining in heart sections after 45min ischemia and 24h reperfusion are shown. Red staining indicates TUNEL-positive cells, and green staining indicates cTnI positive cardiomyocytes. (D) Quantification of apoptotic cardiomyocytes, *, P < 0.05, n=6.
