Table 1.
Islet Clinical Trials (clinicaltrials.gov, accessed Jan 31, 2015)
| Sponsor | Title of Trial | Phase | Registry No.* |
|---|---|---|---|
| Viacyte, San Diego, CA, USA | ESC in Macrodevice | I/II | NCT02239354 |
| University of Miami/Diabetes Research Institute, Miami, FL, USA | Allogeneic Islet Transplant into the Omentum | I/II | NCT 02213003 |
| Vrije Universiteit Brussel, Brussels, Belgium | Long Term Function of Beta Cell Allografts in Non-Uremic T1D Patients | I/II | NCT00798785 |
| Ospedale San Raffaele, Milan, Italy | Bone Marrow as an Alternative Site for Islet Transplantation | I | NCT01345227 |
| Ospedale San Raffaele, Milan, Italy | Bone Marrow vs Liver as Site for Islet Transplantation (IsletBOM 2) | I/II | NCT01722682 |
| The Nordic Network For Clinical Islet Transplantation, Sweden and Norway | Intraportal or Intramuscular Site for Islets in Simultaneous Islet and Kidney Transplantation | II | NCT01967186 |
| Uppsala University Hospital, Sweden | Autologous Mesenchymal Stem Cell Transplantation | II | NCT02057211 |
| Uppsala University Hospital, Sweden | Beta/Air Device for Encapsulation of Transplanted Human islets | I/II | NCT02064309 |
| Cliniques Universitaires Saint-Luc-Université Catholique de Louvain, Leuven, Belgium | Encapsulated Human Islets in a "Monolayer Cellular Device" | I | NCT00790257 |
| Novocell, Irvine, CA, USA | Allogeneic Cultured Islet Cells (Human); Encapsulated | I/II | NCT00260234 |
| Living Cell Technologies, Auckland, New Zealand | Alginate-Encapsulated Porcine Islets for Xenotransplantation | I/II |
NCT00940173 NCT01736228 NCT01739829 |
| Vrije Universiteit Brussel, Brussels, Belgium | Transplantation of Encapsulated Beta Cells | II | NCT01379729 |
| Fuzhou General Hospital, Xiamen University, China | Cotransplantation of Islet and Mesenchymal Stem Cell | I/II | NCT00646724 |
| University of Alberta, Edmonton, BC, Canada | Sernova Cell Pouch | I/II | NCT01652911 |
| University of Perugia, Italy | Transplantation of Immunoprotected Pancreatic Islets for the Therapy of Type 1 Diabetes Mellitus (T1DM) | I | ISRCTN43557935 |
| Technische Universität Dresden, Germany | Beta O2 Immunoisolation Device | “individual treatment attempt” | PMID24167261 |
*
NCT: clincialtrials.gov; ISRCTN: isrctn.com; PMID: ncbi.nlm.nih.gov/PubMed