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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Genet Epidemiol. 2015 Apr 17;39(5):366–375. doi: 10.1002/gepi.21901

Table II.

Controlling for Type I Error Rate: Empirical Size

Sample Size 250 500 1000
Environmental Effect 0.00 0.33 0.67 1.00 0.00 0.33 0.67 1.00 0.00 0.33 0.67 1.00
W2WK 0.043 0.045 0.050 0.049 0.050 0.050 0.051 0.047 0.049 0.046 0.051 0.052
Traditional Joint 0.051 0.052 0.056 0.053 0.051 0.048 0.052 0.049 0.052 0.051 0.050 0.047
Traditional Main 0.055 0.053 0.058 0.053 0.051 0.050 0.048 0.053 0.049 0.051 0.049 0.049

Empirical sizes for the W2WK, traditional joint, and traditional main-effect tests at the α=0.05 level. Sample sizes were set to N=250, 500, and 1000. Environmental main effect was allowed to vary from 0, 0.33, 0.67, and 1 (corresponding to R2 values of approximately 0, 0.03, 0.11, and 0.25 respectively).