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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Dev Biol. 2015 May 8;404(1):66–79. doi: 10.1016/j.ydbio.2015.04.025

Fig. 7.

Fig. 7

Speculative model of how the combined activities of end-1 and end-3 must reach a threshold for completely normal E lineage development. Below that threshold, specification may still occur, but it becomes stochastic, in some cases allowing only a subset of E descendants to adopt an intestine fate. Those that have made a relatively normal gut may manifest defects in intestine function at the adult stage. In the complete absence of end-1 and end-3 together, gut specification fails (Owraghi et al., 2010).