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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Genet Epidemiol. 2015 May 13;39(5):325–333. doi: 10.1002/gepi.21903

Figure 1.

Figure 1

Summed minor allele frequency (sMAF) of risk variants in cases (solid lines) and controls (broken lines) under different study designs. We show sMAF as a function of mean relative risk of risk variants for (a) TRAFIC, (b) the conventional case-control design, and (c) the selected cases design for summed allele frequencies (f) of 0.01, 0.05 and 0.2 and fixed variance of relative risk σ2 = 0.