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Summed minor allele frequency (sMAF) of risk variants in cases (solid lines) and controls (broken lines) under different study designs. We show sMAF as a function of variance of relative risk between risk variants for (a) TRAFIC, (b) the conventional case-control design, and (c) the selected cases design for summed allele frequencies (f) of 0.01, 0.05 and 0.2 and fixed mean relative risk μ = 1.15.
