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The analytical power curve for TRAFIC, conventional case-control, and selected cases design for different summed allele frequencies (f). Row (a) displays the power as a function of mean relative risk evaluated at variance of relative risk σ2 = 0. Row (b) shows the power as a function of variance of relative risk evaluated at mean relative risk μ = 1.5. Results are shown for 2000 individuals (1000 sibpairs or 1000 cases and 1000 controls) at a significance level 2.5×10−6.
