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The effects of acute and two-day ketamine administration on LC NE neuron firing. Mean (± SEM) of the firing rate and burst activity of NE neurons following acute (a) and (b) and two-day (c) and (d) administration of vehicle or ketamine (10 mg/kg). The numbers in the histograms correspond to either the number of neurons recorded (a) and (c) or the number of rats tested per group (b) and (d). **p < 0.01; *p < 0.05.
