Figure 4.

The effects of acute ketamine administration on the responsiveness of AMPA and NMDA receptors. Integrated firing rate histograms of dorsal hippocampus CA3 pyramidal neurons showing their responsiveness to ketamine administration (indicated by arrows) at a dose of 10 mg/kg (a), and 25 mg/kg (b). Horizontal bars indicate the duration of iontophoretic applications of AMPA (black) or NMDA (white). Ejection currents of -1 nA for AMPA and -8 nA for NMDA were used in this example. In (c) and (d), results are expressed as overall changes in the percent of baseline firing rate of dorsal hippocampus CA3 pyramidal neurons following administration of ketamine or vehicle; *p<0.05.