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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2015 May 15;11(7):1099–1114. doi: 10.1517/17425255.2015.1043887

Figure 2.

Figure 2

Crystal structures of the CAR LBD (cartoon representation) in complex with a ligand (stick representation) A) hCAR with CITCO (pdb 1XVP); B) mCAR with androstenol (pdb 1XNX); C) hCAR with 5β-pregnanedione (pdb 1XV9); D) mCAR with TCPOBOP (pdb 1XLS). Oxygen, nitrogen, and chlorine atoms are depicted in red, blue, and dark green, respectively. The residues Phe161, Asn165, Phe234, and Tyr326 (Figure 2A, carbon atoms in orange) form the barrier that obstructs ligand access to the AF-2 helix and helix-x residues Leu336, Met340, Leu343 and Cys347 (carbon atoms in purple). All structures are depicted in the same orientation for comparison.