Table 2. Clinical features associated with response to intravitreal bevacizumab at postoperative 1 month and at last visit.
Overall |
At 1 month after the first IVB |
At the last visit |
|||||
---|---|---|---|---|---|---|---|
CR group (n=10) | NCR group (n=32) | P-value | CR group (n=25) | NCR group (n=17) | P-value | ||
Demography | |||||||
Age (years) | 49.4±11.1 | 45.4±7.8 | 50.6±11.7 | 0.101a | 47.5±9.2 | 52.1 ±13.1 | 0.298a |
Male/female | 26/16 | 7/3 | 19/13 | 0.715b | 16/9 | 10/7 | 0.757c |
Symptom duration (months) | 6.8±10.5 | 6.7±7.3 | 6.8±11.4 | 0.336a | 7.0±8.7 | 6.4±13.0 | 0.286a |
Spherical equivalent (diopters) | -0.45±1.15 | -0.28±1.27 | -0.52±1.13 | 0.950a | -0.38±1.19 | -0.52±1.15 | 0.823a |
BCVA at baseline (LogMAR) | 0.3±0.3 | 0.1±0.1 | 0.4±0.4 | 0.002a | 0.3±0.3 | 0.4±0.4 | 0.424a |
FA features | |||||||
Classic/DRPE | 27/12 | 5/5 | 22/7 | 0.232b | 19/4 | 8/8 | 0.041b |
From leakage to fovea (μm) | 796.6±484.1 | 886.8±644.2 | 766.5±429.1 | 0.747a | 752.1±339.4 | 866.4±660.6 | 0.936a |
ICGA features (presence/absence) | |||||||
Choroidal hyperpermeability | 22/0 | 5/0 | 17/0 | NA | 9/0 | 13/0 | NA |
Choroidal filling delay | 16/6 | 5/0 | 11/6 | 0.266b | 6/3 | 10/3 | 0.655b |
Punctate hyperfluorescence | 17/5 | 3/2 | 14/3 | 0.548b | 5/4 | 12/1 | 0.116b |
SD-OCT features (μm) | |||||||
SRF GLD | 3203.7±1058.8 | 2587.7±893.2 | 3396.3±1044.2 | 0.019a | 3232.1±1163.2 | 3162.1±916.5 | 0.929a |
SRF height | 213.4±101.0 | 168.8±76.0 | 227.4±104.8 | 0.090a | 214.7±105.7 | 211.6±96.8 | 0.888a |
SRF volume (mm3) | 1.0±0.8 | 0.7±0.5 | 1.1±0.8 | 0.090a | 1.0±0.8 | 1.0±0.8 | 0.798a |
Central macular thickness | 429.0±107.1 | 395.5±73.1 | 439.4±114.7 | 0.199a | 426.1±102.2 | 433.2±117.1 | 0.858a |
Subfoveal choroidal thickness | 419.6±135.2 | 492.9±96.9 | 389.0±138.7 | 0.036a | 433.3±123.9 | 402.3±150.9 | 0.405a |
Abbreviations: BCVA, best corrected visual acuity; CR, complete resolution of subretinal fluid; DRPE, diffuse retinal pigment epitheliopathy; FA, fluorescein angiography; GLD, greatest linear diameter; ICGA, indocyanine green angiography; LogMAR, logarithm of minimal angle of resolution; NA, not available; NCR, no complete resolution of subretinal fluid; SD-OCT, spectral domain optical coherence tomography; SRF, subretinal fluid.
Mann–Whitney U-test.
Fisher's exact test.
Pearson's χ2 test.