Table 3. Respiratory parameters measured by whole-body barometric plethysmography (WBBP).
| Comparison 1 | Comparison 2 | |||
|---|---|---|---|---|
| Non-brachycephalic controls a (n = 20) | Grade 0 French bulldog controls (n = 9) | BOAS—French bulldogs b (n = 41) | BOAS + French bulldogs b (n = 48) | |
| RR_m | 20.85 ± 2.22 | 22.55 ± 5.87 * | 23.13 ± 2.89 | 22.55 ± 5.04 |
| RR_sd | 5.48 ± 1.22 | 2.84 ± 1.46 | 2.89 ±1.19 | 3.27 ± 1.38 |
| TV/BW_m | 8.77±1.98 | 12.10±3.25** | 9.96±2.57 | 11.05±3.38 |
| TV/BW_sd | 1.30±0.35 | 1.66±0.49 | 1.64±0.62 | 2.16±0.98 τ τ |
| MV/BW_m | 236.83 ± 32.35 | 213.70 ± 27.78 | 215.42 ± 24.53 | 241.46 ± 76.31 τ |
| MV/BW_sd | 28.93 ± 8.43 | 25.07 ± 10.79 | 26.27 ± 8.88 | 40.31 ± 19.01 τ τ τ |
| Te/Ti_m | 1.36 ± 0.16 | 0.962 ± 0.18 *** | 1.06 ± 0.27 π | 1.07 ± 0.39 |
| Te/Ti_sd | 0.20 ± 0.06 | 0.174 ± 0.06 | 0.20 ± 0.07 | 0.29 ± 0.15 τ τ, π |
| PEF/PIF_m | 0.84 ± 0.08 | 1.04 ± 0.14 *** | 0.99 ± 0.15 | 1.32 ± 0.42 τ τ τ |
| PEF/PIF_sd | 0.12 ± 0.04 | 0.142 ± 0.04 | 0.17 ± 0.06 | 0.32 ± 0.18 τ τ τ, π |
Means (m) and standard deviations of the means (sd) of RR, Te/Ti, PEF/PIF, and MV/BW were calculated for 20 breaths collected from each dog.
RR = respiratory rate (breath per minute); Te/Ti = expiratory time (s) /inspiratory time(s); PEF/PIF = peak expiratory flow rate (ml/s)/ peak inspiratory flow rate (ml/s); MV/BW = minute volume (ml)/ body weight(kg); m = mean of the parameter calculated from the 20 breaths of each dog; sd = standard deviation of the parameter calculated from the 20 breaths of each dog.
a Breeds: English springer spaniel (n = 2), Border collie (n = 1), Jack Russell terrier (n = 1), Labrador retriever (n = 3), American bullterrier (n = 1), Beagles (n = 6), Dachshund (n = 1), Cairn terrier (n = 1), West Highland white terrier (n = 1), cross breeds (n = 3).
b BOAS- FB = Grade 0/I FB; BOAS+ FB = Grade II/III FB. Functional grades, refer to Table 1.
π The Kolmogorov-Smironov test was significant (i.e. data were not normal distributed); p<0.05.
* Significantly different from the non-brachycephalic control group, *p<0.05; **p<0.01; ***p<0.001.
τ Significantly different from the BOAS- French bulldogs; τ p<0.05; τ τ p<0.01; τ τ τ p<0.001.