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Terminal elimination of serum APAP-CYS in 28 subjects with normal renal function and 15 subjects with renal failure. The first (highest) APAP-CYS value for each subject’s series was standardized to time zero for pharmacokinetic analysis. Mean ± SEM elimination half-life in renal failure group was 41.3 ± 2.2 h compared to 26.8 ± 1.1 h in those with normal renal function (p < 0.001)
