Table 2.

APAP-CYS removal by CVVHDF

Subject	Blood flow mL/min	Dialysate flow mL/h	Collection time hr	Plasma ultrafiltrate percent	Serum APAP-CYS μM	Dialysate/ultrafiltrate APAP-CYS μM
1	200	1,000	2.6	48	0.46	< 0.01
2	250	2,000	1.2	47.9	1.38	< 0.01
3	200	2,000	1.6	36	6.14	< 0.01
4	250	1,000	1.8	64	6.41	< 0.01
5	250	1,500	1.5	55	6.62	< 0.01
6	200	1,000	1.6	68	7.10	< 0.01
7	250	1,000	1.8	64	7.32	< 0.01
8	240	2,000	1.8	28	9.23	< 0.01
9	200	1,000	1.8	64	9.77	< 0.01

CVVHDF was performed using double-lumen central venous catheters and a Prismaflex® M100 cartridge set (Gambro®, Lakewood, CO.). Collection time refers to time required to collect 5 L of dialysate/ultrafiltrate, from which an aliquot was taken for measurement of APAP-CYS concentration (last column). The percent plasma ultrafiltrate represents the percent of plasma ultrafiltrate in the 5 L collection of ultrafiltrate/dialysate sample used for analysis. Serum APAP-CYS concentrations were measured on blood collected at mid-collection time