Table 1.
Characteristics of individuals in the cohorts involved in the discovery meta-analysis and replication
Sex (% male) | Age stratum | Discovery cohorts |
Replication cohort |
||||
---|---|---|---|---|---|---|---|
ALSPAC (N = 7,916; n = 69,297) |
Raine (N = 1,461; n = 8,670) |
NFBC1966 (N = 3,918; n = 48,530) |
|||||
51.27 |
51.54 |
49.74 |
|||||
N | Mean (SD) | N | Mean (SD) | Na | Mean (SD) | ||
BMI (kg/m2) | 1–1.49 | 2372 | 17.42 (1.51) | 1326 | 17.11 (1.39) | 3304 | 17.66 (1.57) |
1.5–2.49 | 5490 | 16.82 (1.49) | 389 | 16.00 (1.25) | 2769 | 16.81 (1.43) | |
2.5–3.49 | 1679 | 16.48 (1.40) | 957 | 16.14 (1.24) | 2252 | 16.13 (1.29) | |
3.5–4.49 | 5949 | 16.25 (1.39) | 20 | 15.92 (1.41) | 2194 | 15.76 (1.32) | |
4.5–5.49 | 1602 | 16.02 (1.70) | 3 | 15.94 (1.43) | 1967 | 15.47 (1.31) | |
5.5–6.49 | 3322 | 15.71 (1.87) | 1273 | 15.85 (1.70) | 1870 | 15.44 (1.54) | |
6.5–7.49 | 2728 | 16.10 (1.98) | 43 | 16.64 (2.85) | 3040 | 15.56 (1.61) | |
7.5–8.49 | 3588 | 16.30 (2.01) | 1045 | 16.89 (2.52) | 2629 | 15.89 (1.76) | |
8.5–9.49 | 4376 | 17.15 (2.41) | 205 | 16.95 (2.57) | 1965 | 16.32 (2.00) | |
9.5–10.49 | 5516 | 17.67 (2.81) | 304 | 18.95 (3.43) | 2056 | 16.88 (2.24) | |
10.5–11.49 | 4710 | 18.25 (3.10) | 933 | 18.66 (3.41) | 2619 | 17.32 (2.42) | |
11.5–12.49 | 5116 | 19.04 (3.35) | 4 | 16.78 (2.65) | 2911 | 17.80 (2.53) | |
12.5–13.49 | 5268 | 19.64 (3.35) | 9 | 21.11 (3.76) | 2175 | 18.58 (2.67) | |
13.5–14.49 | 4603 | 20.30 (3.44) | 1201 | 21.46 (4.17) | 2383 | 19.25 (2.71) | |
14.5–15.49 | 2342 | 21.28 (3.48) | 24 | 21.66 (4.23) | 2387 | 19.77 (2.66) | |
15.5–16.49 | 1659 | 21.39 (3.51) | 2 | 20.14 (3.26) | 1191 | 20.47 (2.88) | |
16.5+ | 91 | 22.46 (3.39) | 931 | 23.02 (4.37) | 970 | 20.83 (2.66) | |
Weight (kg) | 1–1.49 | 2372 | 10.56 (1.31) | 1326 | 10.33 (1.22) | 3304 | 10.52 (1.25) |
1.5–2.49 | 5490 | 12.01 (1.49) | 389 | 12.98 (1.49) | 2769 | 12.29 (1.46) | |
2.5–3.49 | 1679 | 14.72 (1.89) | 957 | 15.03 (1.81) | 2252 | 14.34 (1.69) | |
3.5–4.49 | 5949 | 16.51 (2.03) | 20 | 15.34 (1.94) | 2194 | 16.27 (2.01) | |
4.5–5.49 | 1602 | 19.42 (2.83) | 3 | 21.97 (1.90) | 1967 | 18.17 (2.34) | |
5.5–6.49 | 3322 | 21.32 (3.37) | 1273 | 21.45 (3.27) | 1870 | 20.39 (3.01) | |
6.5–7.49 | 2728 | 24.98 (4.29) | 43 | 26.00 (5.89) | 3040 | 22.62 (3.46) | |
7.5–8.49 | 3588 | 26.42 (4.68) | 1045 | 28.26 (5.62) | 2629 | 25.04 (4.10) | |
8.5–9.49 | 4376 | 30.33 (5.79) | 205 | 29.75 (5.85) | 1965 | 28.37 (4.88) | |
9.5–10.49 | 5516 | 34.71 (7.30) | 304 | 39.24 (9.06) | 2056 | 31.88 (5.90) | |
10.5–11.49 | 4710 | 38.26 (8.46) | 933 | 39.07 (9.07) | 2619 | 35.32 (6.77) | |
11.5–12.49 | 5116 | 43.60 (9.91) | 4 | 35.85 (6.32) | 2911 | 39.05 (7.78) | |
12.5–13.49 | 5268 | 49.41 (10.58) | 9 | 55.34 (11.15) | 2175 | 44.82 (8.88) | |
13.5–14.49 | 4603 | 54.43 (11.11) | 1201 | 58.47 (13.17) | 2383 | 49.77 (9.14) | |
14.5–15.49 | 2342 | 61.05 (11.85) | 24 | 61.06 (12.74) | 2387 | 53.71 (9.22) | |
15.5–16.49 | 1659 | 61.75 (11.64) | 2 | 57.63 (13.40) | 1191 | 58.02 (9.80) | |
16.5+ | 91 | 64.64 (11.74) | 931 | 68.79 (14.62) | 970 | 59.94 (9.35) | |
Height (m) | 1–1.49 | 2372 | 0.78 (0.04) | 1326 | 0.78 (0.03) | 3304 | 0.77 (0.03) |
1.5–2.49 | 5490 | 0.84 (0.04) | 389 | 0.90 (0.04) | 2769 | 0.85 (0.04) | |
2.5–3.49 | 1679 | 0.94 (0.04) | 957 | 0.96 (0.04) | 2252 | 0.94 (0.04) | |
3.5–4.49 | 5949 | 1.01 (0.04) | 20 | 0.98 (0.04) | 2194 | 1.02 (0.04) | |
4.5–5.49 | 1602 | 1.10 (0.05) | 3 | 1.18 (0.08) | 1967 | 1.08 (0.05) | |
5.5–6.49 | 3322 | 1.16 (0.06) | 1273 | 1.16 (0.05) | 1870 | 1.15 (0.05) | |
6.5–7.49 | 2728 | 1.24 (0.06) | 43 | 1.25 (0.06) | 3040 | 1.20 (0.05) | |
7.5–8.49 | 3588 | 1.27 (0.06) | 1045 | 1.29 (0.06) | 2629 | 1.25 (0.06) | |
8.5–9.49 | 4376 | 1.33 (0.06) | 205 | 1.32 (0.05) | 1965 | 1.32 (0.06) | |
9.5–10.49 | 5516 | 1.40 (0.06) | 304 | 1.43 (0.06) | 2056 | 1.37 (0.06) | |
10.5–11.49 | 4710 | 1.44 (0.07) | 933 | 1.44 (0.07) | 2619 | 1.42 (0.07) | |
11.5–12.49 | 5116 | 1.51 (0.07) | 4 | 1.46 (0.05) | 2911 | 1.48 (0.07) | |
12.5–13.49 | 5268 | 1.58 (0.08) | 9 | 1.62 (0.06) | 2175 | 1.55 (0.08) | |
13.5–14.49 | 4603 | 1.63 (0.08) | 1201 | 1.65 (0.08) | 2383 | 1.60 (0.08) | |
14.5–15.49 | 2342 | 1.69 (0.08) | 24 | 1.68 (0.06) | 2387 | 1.65 (0.08) | |
15.5–16.49 | 1659 | 1.70 (0.08) | 2 | 1.69 (0.06) | 1191 | 1.68 (0.08) | |
16.5+ | 91 | 1.69 (0.08) | 931 | 1.73 (0.10) | 970 | 1.70 (0.08) |
aDue to the data structure in NFBC1966, some individuals had multiple measures within a 1-year period. This column is the number of unique individuals with measures in the age bracket.