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. 2015 Jun 6;44(2):512–525. doi: 10.1093/ije/dyv080

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© The Author 2015; Published by Oxford University Press on behalf of the International Epidemiological Association.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Genetic associations with blood pressure and coronary artery disease risk from 29 variants—funnel plots of minor allele frequency corrected genetic associations with blood pressure ( ${\hat{γ}}_{j}^{C}$ ) against causal estimates of blood pressure on CAD based on each genetic variant individually ( ${\hat{β}}_{j}$ ). Left: funnel plot for systolic blood pressure. Right: funnel plot for diastolic blood pressure. The inverse-variance weighted (IVW) and MR-Egger causal effect estimates are also shown.