Fig. 2.

Meal patterns after intra-VTA administration of suprathreshold doses of amylin (0.4 μg) or its vehicle (100 nl of aCSF) plus leptin (0.3 μg) or its vehicle (100 nl of 0.01 M sodium bicarbonate). The hypophagia produced by VTA amylin combined with VTA leptin shown in Fig. 1 is driven primarily by reductions in meal size (A) rather than meal number (B). Within a time bin: #statistical significance (P < 0.05) compared with Veh/Veh; *significant difference (P < 0.05) from all other conditions. All data shown as means ± SE.