Table 1.

Number of animals randomized to 24-h infusions with diluent and PA alone (control), LT, or ET and then sampled at 8, 24, or 48 h after the start of infusion in each of 16 experiments in study 1 for echocardiography and perfused heart measures and 10 experiments in study 2 for electron microscopy measures

	Control Group				LT Group				ET Group
	Randomized	Sampled at 8 h	Sampled at 24 h	Sampled at 48 h	Randomized	Sampled at 8 h	Sampled at 24 h	Sampled at 48 h	Randomized	Sampled at 8 h	Sampled at 24 h	Sampled at 48 h
Study 1
Experiment 1	2		1	1	4		1	1	3		1	1
Experiment 2	2		1	1	3		1	1	3		1	1
Experiment 3	2		1	1	4		1	1	4		1	1
Experiment 4	2		1		3		1	1	3		1	2
Experiment 5	2		1	1	4		1		4		1	1
Experiment 6	2			1	3		2	1	3		1
Experiment 7	2	1		1	4	1		1	3	1
Experiment 8	2	1		1	5	1		1	5	1		2
Experiment 9	2	1		1	4	1		2	4	1		1
Experiment 10	2	1		1	5	1		1	5	1		2
Experiment 11	2	1		1	4	1		2	4	1		1
Experiment 12	1			1	3	1		2	3	1		1
Experiment 13*	1		1		3		2		2		2
Experiment 14*	2		2		3		2		2		2
Experiment 15*	2		2		4		2		2		2
Experiment 16*	3		3		3		1		2		2
Study 2
Experiment 1	2	1	1		2	1			3	1	1
Experiment 2	1		1		2	1			3	1
Experiment 3	1		1		1		1		3		1
Experiment 4	2	1	1		2	1	1		2	1	1
Experiment 5	2	1			2	1	1		4	1	1
Experiment 6	1	1			2		1		1
Experiment 7	1	1			3	1	1		2	1
Experiment 8	5	1	1	3	9	1	1	2	10	1	1
Experiment 9	4	1	1	2	9	1	1	2	11	1	1	2
Experiment 10	1			1	4				11			3

PA, protective antigen; LT, lethal toxin; ET, edema toxin.

^*These experiments tested hemodynamics, perfused isolated heart function, and effluent myocardial biomarkers and cAMP only.