Table 2.

Mean (±SE) values for echocardiography, electron microscopy, chemistry, and arterial blood gas measures for control animals at 8, 24 and 48 h after the start of an infusion of diluent with Protective Antigen only

	Echocardiography
	End-systolic volume, μl	End-diastolic volume, μl	Ejection fraction, %	Heart rate, beats/min	Stroke volume, μl	Cardiac output, ml/min
8 h	59.2 ± 12.6	257.8 ± 24.8	77.9 ± 3.5	393 ± 22	198 ± 20	77.4 ± 7.5
24 h	81.5 ± 12.6	309.7 ± 24.8	74.5 ± 3.5	356 ± 25	228 ± 20	83.2 ± 8.4
48 h	77.1 ± 8.5	309.9 ± 16.7	75.1 ± 2.3	320 ± 15	233 ± 13	74.7 ± 5.1

	Electron Microscopy
	Endothelial membrane	Endothelial nucleus	Myocyte mitochondria outer membrane	Myocyte mitochondria inner membrane	Myocyte sarcomere	Myocyte nucleus
8 h	8.3 ± 1.9	7.8 ± 1.7	8.8 ± 2.0	6.8 ± 2.0	8.9 ± 2.1	7.9 ± 1.6
24 h	6.6 ± 2.2	6.8 ± 2.5	9.4 ± 2.4	8.9 ± 2.2	9.1 ± 2.3	8.6 ± 1.8
48 h	7.7 ± 1.6	7.2 ± 1.1	6.5 ± 1.2	8.1 ± 1.9	5.81.5	7.6 ± 1.5

	Plasma Chemistry
	CPK, U/l	cTnI, ln(ng/ml)	ALT, U/l	AST, U/l	BUN, mg/dl	Creatinine, mg/dl
8 h	431 ± 143	0.01 ± 0.07	52.0 ± 34.3	160 ± 101	16.6 ± 9.3	0.34 ± 0.09
24 h	235 ± 120	0.10 ± 0.05	31.7 ± 28.7	128 ± 84	17.6 ± 7.8	0.31 ± 0.07
48 h	299 ± 115	0.00 ± 0.06	44.6 ± 26.2	213 ± 77	21.8 ± 7.1	0.25 ± 0.07

	Arterial Blood Gas
	pH	Lactate, mmol/l	ABE, mmol/l	Na+, mmol/l	K+, mmol/l
8 h	7.47 ± 0.01	1.25 ± 0.27	2.52 ± 0.69	141.6 ± 0.6	3.41 ± 0.14
24 h	7.47 ± 0.01	1.01 ± 0.30	1.05 ± 0.78	141.8 ± 0.7	3.43 ± 0.17
48 h	7.47 ± 0.01	1.05 ± 0.40	1.98 ± 1.05	141.6 ± 0.8	3.28 ± 0.18

CPK, creatine phosphokinase; cTnI, cardiac troponin I; ALT, alanine aminotransferase; AST, aspartate aminotransferases; BUN, blood urea nitrogen; ABE, arterial base excess.