Fig. 2.

RV phosphodiesterase 5 (PDE5) expression is increased after 14 days of exposure to CH but normalizes with RA recovery. PDE5 expression was measured at 3 time points: 14 day mice, 28 day mice (14 day exposure and 14 day recovery), and 56 day mice (14 day exposure, 42 day recovery). A: RV PDE5 expression was measured by Western blot in CH mice (n = 7, 11, and 8, respectively) vs. age-matched RA controls (n = 11, 10, and 8, respectively). Data are shown as fold ± SE. *P < 0.05 vs. age-matched controls. B: representative Western blots of RV PDE5 expression were normalized to β-actin of CH vs. RA mice in the 3 different age groups.