Fig. 3.

Representative traces showing SSNA, RSNA, and ABP responses to bilateral PVN microinjection of the SK channel blocker apamin (12.5 pmol) in a rat on a HS diet alone (left) or systemic ANG II infusion alone (right). A: bilateral PVN injection (50 nl each) of apamin (arrowheads) in a rat with HS intake increased SSNA, RSNA, and ABP in a similar manner to a rat with ANG II-salt HTN (Fig. 1, right). Bilateral injection (50 nl each) of apamin (arrowheads) in a rat with systemic ANG II infusion increased ABP in a similar manner to a rat on NS control diet, whereas SSNA and RSNA responses were obviously attenuated compared with the NS-fed control rat (Fig. 1, left). B, left: 5-s trace of SSNA (top) and RSNA (bottom) before injection of apamin into the PVN. Right, 5-s trace of SSNA (top) and RSNA (bottom) after injection of apamin into the PVN.