Fig. 3.

Effect of a high-sodium diet (HSD) on urinary parameters in WT and TG mice. Groups of mice (n = 6 mice/genotype) were given an HSD (3.51% Na) for 13 days. To monitor 24-h urinary parameters mice were placed in metabolic cages (one mouse/cage). Means ± SE values obtained on days 0, 1, 4, 8, and 13 of the experimental period were presented for urine output (A), urine osmolality (B), and urine sodium (C). To compensate for differences in body weights of individual mice, the values for urine output and urine sodium were adjusted to 20 g body wt. *P <0.05 compared with the corresponding time point in the WT mice by unpaired t-test.