Fig. 10.

A folic acid-enriched diet enhances T+E2 bladder sensitivity to afferent stimulation. Adult male mice were treated as described in Fig. 1. At 2 mo postsurgery, capsaicin was administered by intravesicular infusion into urethane-anesthetized mice. The following parameters were determined: intervoid interval of sustained voids (3 more drops) before vs. after capsaicin infusion (A), number of voiding events defined as the number of drip voids (1–2 drops) occurring over the course of a 6-sustained void (3 or more drops) interval following capsaicin infusion (B), and time back to baseline after peak voiding pressure (C). Values are means ± SE.*Significant difference, P ≤ 0.05; n ≥3/group.