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A folic acid-enriched diet increases T+E2-induced Trpv1 mRNA abundance and dorsal root ganglia (DRG) global DNA methylation. Adult male mice were treated as described in Fig. 1. A: relative abundance of Trpv1 mRNA in L6 and S1 dorsal root ganglia 2 mo postsurgery. B: global DNA methylation in DRG 2 mo postsurgery. Values are means ± SE. *Significant difference, P ≤ 0.05; n ≥3/group.
