Fig. 8.

T+E2 reduces bladder contractility. Adult male mice were treated as described in Fig. 1. Relative bladder contractility (percent maximum response to KCl normalized to bladder mass) was determined in isolated bladder strips exposed to graded concentrations of the cholinergic agonist carbachol. Values are means ± SE. *Significant difference, P ≤ 0.05. Vertical bars indicate differences between treatment groups, and horizontal bars indicate differences over time. #Significant interaction between change in carbachol concentration and treatment group, P ≤ 0.05; n = 5/group.