Table 1.
Changes in obesity, lipid, metabolic, kidney function, and QoL parameters before and 12 months after bariatric surgery
| Variable | Baseline | 12 months | Change | p |
|---|---|---|---|---|
| Obesity measures* | ||||
| Weight (kg) | 160.3 [123.5, 172.0] | 109.0 [96.1, 125.3] | −30.7 [−38.9, −24.0] | <0.001 |
| Height (cm) | 176.5 [172.0, 181.9] | -- | -- | |
| BMI (kg/m2) | 51.0 [36.8, 57.8] | 34.4 [30.8, 46.7] | −9.3 [−14.0, −8.1] | <0.001 |
| Waist circumference (cm) | 138.5 [122.0, 157.5] | 118.5 [106.0, 130.0] | −21.8 [−25.3, −15.0] | <0.001 |
| Fat% | 47.2 [40.1, 53.2] | 34.2 [30.2, 44.6] | −10.2 [−15.7, −5.3] | <0.001 |
| Fat mass (kg) | 68.3 [46.0, 89.2] | 37.4 [28.6, 59.8] | −24.8 [−31.5, −20.4] | <0.001 |
| Fat-free mass (kg) | 72.1 [68.5, 87.7] | 68.4 [64.1, 77.6] | −7.6 [−10.1, −3.2] | 0.002 |
| Lipid parameters | ||||
| Total cholesterol (mg/dl) | 134.0 [122.0, 146.0] | 133.0 [107.0, 138.0] | −13.0 [−26.0, 15.0] | 0.3 |
| HDL cholesterol (mg/dl) | 34.0 [31.0, 38.0] | 44.0 [38.0, 61.0] | +11.0 [8.0, 14.0] | 0.001 |
| Serum triglycerides (mg/dl) | 156.0 [106.0, 183.0] | 99.0 [75.0, 119.0] | −54.0 [−90.0, 2.0] | 0.05 |
| LDL Cholesterol (mg/dl) | 60.2 [47.6, 71.8] | 57.4 [46.8, 69.2] | −0.80 [−23.0, 6.6] | 0.5 |
| Metabolic Parameters | ||||
| Log(hs-CRP) | 0.98 [0.90, 1.00] | 0.30 [−0.18, 0.76] | −0.56 [−1.1, −0.24] | <0.001 |
| HOMA-IR | 18.6 [5.2, 34.1] | 4.8 [3.0, 6.0] | −13.8 [−29.2, −1.5] | 0.008 |
| Matsuda index | 0.91 [0.42, 1.9] | 2.4 [1.9, 2.7] | 1.5 [0.51, 2.2] | 0.04 |
| HMW Adiponectin | 2244 [1654, 3438] | 6617 [2696, 7771] | 1939 [869, 5559] | <0.001 |
| Total Adiponectin | 4815 [4339, 7858] | 14491 [5837, 17756] | 8329 [1021, 12180] | <0.001 |
| Leptin | 37.8 [22.8, 60.8] | 10.6 [6.0, 16.1] | −15.7 [−26.2, −7.2] | 0.001 |
| Kidney function* | ||||
| Serum creatinine (mg/dl) | 1.6 [1.5, 1.8] | 1.4 [1.2, 1.6] | −0.27 [−0.34, −0.08] | 0.006 |
| Cystatin C (mg/dl) | 1.8 [1.7, 1.9] | 1.6 [1.5, 2.0] | 0.02 [−0.17, 0.10] | 0.5 |
| B2M (mg/dl) | 3.5 [3.3, 3.8] | 3.5 [2.9, 3.8] | 0.00 [−0.40, 0.40] | 0.9 |
| eGFRcr (ml/min) | 47.7 [37.4, 52.4] | 52.3 [45.1, 63.8] | 7.9 [0.77, 16.2] | 0.01 |
| eGFRcr (ml/min/1.73 m2) | 30.5 [26.8, 34.5] | 36.5 [35.9, 44.8] | 11.0 [3.9, 14.3] | <0.001 |
| eGFRcys (ml/min) | 34.6 [33.4, 37.7] | 41.7 [31.0, 46.2] | −0.73 [−2.5, 10.9] | 0.3 |
| eGFRcys (ml/min/1.73 m2) | 23.7 [22.4, 29.0] | 28.9 [24.6, 34.9] | 2.2 [0.57, 10.7] | 0.003 |
| eGFRcr-cys (ml/min) | 41.6 [32.3, 47.2] | 45.8 [34.6, 56.3] | 4.8 [0.82, 9.2] | 0.02 |
| eGFRcr-cys (ml/min/1.73 m2) | 26.0 [25.2, 31.5] | 34.3 [26.8, 41.9] | 6.3 [3.4, 10.4] | <0.001 |
| mGFR (ml/min) | 82.0 [60.9, 89.7] | 80.5 [63.0, 111.5] | 1.2 [−1.6, 10.9] | 0.3 |
| mGFR (ml/min/1.73 m2) | 50.0 [44.0, 58.0] | 64.0 [48.0, 87.0] | 8.0 [5.0, 12.0] | 0.02 |
| 24-h Proteinuria (g) | 0.60 [0.16, 1.60] | 0.43 [0.16, 0.85] | −0.02 [−0.28, 0.28] | 0.8 |
| QoL composite score | ||||
| SF-12 Physical Health | 39.8[25.3,47.8] | 49.1[42.1,51.6] | 4.9[0.77,19.3] | 0.007 |
| SF-12 Mental Health | 49.9[40.1,57.8] | 56.4[48.9,58.2] | 2.8[−1.6,11.6] | 0.2 |
N = 13. Values are given as median [interquartile range].
*
Wilcoxon signed rank test
Abbreviations: B2M, β2-microglobulin; BMI, body mass index; cr, creatinine; cys, cystatin C; m/eGFR: measured/estimated glomerular filtration rate; HOMA-IR: homeostatic model assessment of insulin resistance; hs-CRP, high-sensitivity C-Reactive Protein; HMW, high-molecular-weight; SF-12, 12-Item Short Form Health Survey; HDL, high-density lipoprotein; LDL, low-density lipoprotein