Table 3.
Fibrogenic/angiogenic growth factors in wound fluids from /HeOuJ and /HeJ mice
| Postwound day | Strain | TGF-β (ng/mL) | FGF2 (pg/mL) | VEGF (pg/mL) |
|---|---|---|---|---|
| 1 | /HeOuJ | 1.2 ± 0.2 | 129 ± 10 | 231 ± 16 |
| /HeJ | 1.2 ± 0.2 | 114 ± 20 | 234 ± 31 | |
| 7 | /HeOuJ | 2.9 ± 0.9b | 48 ± 6 | 473 ± 133b |
| /HeJ | 2.6 ± 0.3b | 49 ± 7 | 610 ± 153b | |
| 21 | /HeOuJ | 5.1 ± 0.7b,c | 140 ± 48 | 600 ± 176b,c |
| /HeJ | 6.5 ± 1.2a,b,c | 411 ± 251a,b,c | 499 ± 179b,c |
Wound fluids collected from /HeOuJ or /HeJ mice (six animals per strain and time point) were analyzed for TGF-β, FGF2, and VEGF by ELISA. Data are means ± SD. Results were analyzed by two-way ANOVA/Newman–Keuls. For each assay
a
indicates p < 0.05 /HeOuJ vs. /HeJ for the indicated postwound day. Within each strain and assay
b
indicates p < 0.05 vs. postwound day 1
c
indicates p < 0.05 vs. postwound day 7.
ANOVA, analysis of variance; ELISA, enzyme-linked immunosorbent assay; FGF2, fibroblast growth factor 2; TGF-β, transforming growth factor-β; VEGF, vascular endothelial growth factor.