Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
BIX01294 suppresses VEGFR-2 and FAK-mediated signaling pathways. (A) HUVECs were treated with various concentrations of BIX01294 and stimulated with VEGF (20 ng/ml) for 15 min. Activation of VEGFR-2, FAK, and paxillin was determined by Western blot. (B) HUVECs were stimulated with VEGF (20 ng/ml) in the presence or absence of BIX01294, and then filamentous actin was visualized by immunofluorescent staining using Alexa Fluor 488-conjugated phalloidin.
